IMMUNOHISTOCHEMICAL FEATURES OF MUCINOUS BORDERLINE OVARIAN TUMOR. CLINICAL CASE ANALYSIS

DOI: 10.22138/2500-0918-2021-18-3-217-223

G.S. Gozman

Kirov State Medical University, Kirov, Russian Federation

Abstract. To describe the immunohistochemical features and the histological picture of mucinous borderline ovarian tumor, to determine their significance for the diagnosis.
Materials and methods. The patient’s medical history was analyzed, as well as the results of histological and immunohistochemical studies on histological preparations of postoperative material — a removed ovarian tumor.
Results. In the micropreparation of the cyst of the right ovary, sections of the formation of the ovary are presented, the proliferating epithelium of the mucinous type is determined, the atypia of the cell nuclei, the activity of mitosis are determined, there are papillary growths, branching glandular structures, there are areas of deposition of psammological bodies. No invasion of the organ stroma was found. This histological picture corresponds to a mucinous borderline tumor of the ovary. Due to the complexity and diversity of the histological structure of ovarian tumors, an immunohistochemical study is used for the final confirmation of the diagnosis. Immunohistochemical study of postoperative material was carried out using antibodies WT-1, p53, Napsin A, ER, PR, PAX8, CK7, CK20, CDX2, Ki-67.
Conclusions. On the example of this clinical case, the immunohistochemical features of a mucinous borderline ovarian tumor were established. Accordingly, the diagnosis of mucinous borderline ovarian tumor was confirmed.

Keywords: ovarian tumor, mucinous borderline ovarian tumor, immunohistochemistry

There is no conflict of interest.
Contact details of the corresponding author:
Elena S. Gozman
alenablumari@yandex.ru
Received 11.05.2021
For citation:
Gozman G.S. Immunohistochemical features of mucinous borderline ovarian tumor. Clinical case analysis. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2021, Vol. 18, no. 3, pp. 217–223. DOI: 10.22138/2500-0918-2021-18-3-217-223 (In Russ)

REFERENCES
1. Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment / V. Rojas [et al.] Int J Mol Sci. – 2016. –Vol. 17 (12). –Р.E2113.
2. Karseladze, A.I., Morfologiya epitelial’nyh opuholej yaichnika (voprosy morfologicheskoj semiotiki, gisto- i morfogeneza): dis. …d-ramed. nauk: 14.00.14, 14.00.15. Karseladze Apollon Irodionovich. — M., 1989. — 376 s. (In Russian)
3. Davydova, I.Yu. Seroznye pogranichnye opuholi yaichnikov: kliniko-morfologicheskie osobennosti, lechenie, prognoz: dis. d-ramed. nauk: 14.01.12. Davydova Irina Yur’evna. — M., 2018. — S. 4-6. (In Russian)
4. Rasmussen E.L.K., Hannibal C.G., Dehlendorff C. et al. Parity, infertility, oral contraceptives, and hormone replacement therapy and the risk of ovarian serous borderline tumors: A nationwide case-control study. Gynecol Oncol. 2017; 144 (3): 571-6. DOI: 10.1016/j.ygyno.2017.01.002.
5. Davydova, I.Yu. Pogranichnye opuholi yaichnikov: voprosy himioterapii i prognoza / I.Yu. Davydova, V.V. Kuznecov, A.I. Karseladze, L.A. Meshcheryakova. Opuholi zhensko jreproduktivnoj sistemy. — 2015. — T. 11, № 3. — S. 72-75. (In Russian)
6. Novikova, E. G. Pogranichnye opuholi yaichnikov. E.G. Novikova, G.Yu. Batalova. –M.: OOO «Medicinskoe informacionnoe agentstvo», 2007.–151 s. (In Russian)
7. WHO Classificaihion of Tumours of Female Reproductive Organs. Fourth Edition. R. J. Kurman [et al.].– IARS: Lyon, 2014. – 307 p.
8. Davydova, I. Yu. Seroznye pogranichnye opuholi yaichnikov (klinicheskoetechenie, morfologiya, lechenie). I. Yu. Davydova, V. V. Kuznecov, A. I. Karseladze. Opuholi zhenskoj reproduktivnoj sistemy. – 2012. – № 3-4. – S. 165–168. (In Russian)

Author
Elena S. Gozman
Kirov State Medical University of the Ministry of Health of Russia
2-year post-graduate student of the Department of Histology, Embryology and Cytology
112 K.Marks Str. Kirov Russian Federation 610998
alenablumari@yandex.ru

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)